细胞周期蛋白D1
套细胞淋巴瘤
癌症研究
细胞周期蛋白D
生物
细胞周期蛋白
细胞周期蛋白A2
细胞周期蛋白B
细胞周期
染色质
周期素D2抗原
淋巴瘤
基因
遗传学
免疫学
作者
Santiago Demajo,Robert Albero,Guillem Clot,Giancarlo Castellano,Alba Navarro,Cristina Capdevila,Anna Enjuanes,Ferran Nadeu,Eva Giné,Magda Pinyol,Elaine S. Jaffe,German Ott,Louis M. Staudt,Andreas Rosenwald,David W. Scott,Lisa M. Rimsza,Armando López‐Guillermo,Sı́lvia Beà,Elı́as Campo,Pedro Jares
标识
DOI：10.1158/1078-0432.ccr-20-2868
摘要
Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation leading to cyclin D1 overexpression. Cyclin D1 is a major cell-cycle regulator and also regulates transcription, but the impact of cyclin D1-mediated transcriptional dysregulation on MCL pathogenesis remains poorly understood. The aim of this study was to define a cyclin D1-dependent gene expression program and analyze its prognostic value.
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