已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Prognostic and clinicopathologic value of ki-67 and profilin 1 immunohistochemical expression in primary pT1 urothelial bladder cancer

膀胱癌 医学 免疫组织化学 癌症 内科学 生物标志物 Ki-67 肿瘤科 病理 原位癌 肿瘤进展 生物 生物化学
作者
Meftun Çulpan,Turgay Turan,Sıdıka Şeyma Özkanli,Tülay Zenginkinet,Özgür Kazan,Taha Uçar,Gökhan Atış,Turhan Çaşkurlu,Asıf Yıldırım
出处
期刊:Journal of Cancer Research and Therapeutics [BioMed Central]
卷期号:17 (2): 434-434 被引量:4
标识
DOI:10.4103/jcrt.jcrt_408_19
摘要

To investigate the prognostic and clinicopathologic value of Ki-67 and profilin 1 immunohistochemical expression in primary pT1 papillary urothelial bladder cancer.This study included 88 male and 13 female pT1 primary bladder cancer patients. Demographic characteristics, tumor histological grade, tumor number, presence of concomitant carcinoma in situ, tumor size, and status of recurrence or progression were recorded for each patient. Expression of Ki-67 and profilin 1 was evaluated by immunohistochemical analysis of paraffin-embedded tumor tissues. The Pearson's Chi-square test was used for the analysis of qualitative data, and the Kaplan-Meier method and the log-rank test were used for the survival analysis.In the mean follow-up period of 52 months, 52 (51.5%) patients experienced recurrence, 24 (23.8%) patients experienced progression, and 17 (16.8%) patients died from bladder cancer-related causes. Ki-67 expression was significantly associated with tumor histological grade (P = 0.001). In multivariate analysis, Ki-67 positivity had significantly worse outcome for recurrence (P = 0.006) and mortality (P = 0.022). Ki-67-positive (Ki-67 index ≥15%) patients had shorter recurrence-free (P = 0.003), progression-free (P = 0.002), and cancer-specific (P = 0.003) survival. However, no statistically significant relationship was found between profilin 1 expression and clinicopathologic features and prognosis.Ki-67 is a highly predictive biomarker for recurrence-free, progression-free, and cancer-specific survival in pT1 bladder cancer patients, in whom prediction of recurrence and progression are difficult. Ki-67 expression can be safely combined with other prognostic factors. However, in pT1 bladder cancer patients, no significant relationship was found between profilin 1 expression and tumor characteristics or prognostic parameters.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
CheetahAzure发布了新的文献求助10
4秒前
搜集达人应助敏感的南露采纳,获得20
6秒前
kelien1205完成签到 ,获得积分10
8秒前
所所应助zhangzhi采纳,获得10
10秒前
fly完成签到,获得积分10
10秒前
CheetahAzure完成签到,获得积分10
11秒前
zozox完成签到 ,获得积分10
15秒前
20秒前
fengliurencai完成签到,获得积分10
21秒前
无花果应助WillGUO采纳,获得10
21秒前
28秒前
乐乐应助朴实的热狗采纳,获得10
31秒前
薄红发布了新的文献求助10
34秒前
hhr完成签到 ,获得积分10
36秒前
36秒前
派大星完成签到,获得积分10
36秒前
39秒前
ACTIVE发布了新的文献求助10
39秒前
量子星尘发布了新的文献求助10
41秒前
Murphy完成签到 ,获得积分10
42秒前
46秒前
满满完成签到,获得积分10
46秒前
和谐诗双完成签到 ,获得积分10
48秒前
冷先森EPC完成签到,获得积分10
50秒前
薄红完成签到,获得积分20
51秒前
小菡菡发布了新的文献求助10
52秒前
wzzznh完成签到 ,获得积分10
53秒前
火火火木完成签到 ,获得积分10
53秒前
54秒前
隐形曼青应助yuko采纳,获得10
56秒前
粥粥完成签到 ,获得积分10
56秒前
1234567发布了新的文献求助10
58秒前
好运滚滚来完成签到 ,获得积分10
58秒前
junyang完成签到,获得积分10
1分钟前
xinqianying完成签到 ,获得积分10
1分钟前
1分钟前
朴实的热狗给朴实的热狗的求助进行了留言
1分钟前
1分钟前
ACTIVE完成签到,获得积分20
1分钟前
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976600
求助须知:如何正确求助?哪些是违规求助? 3520674
关于积分的说明 11204422
捐赠科研通 3257298
什么是DOI,文献DOI怎么找? 1798683
邀请新用户注册赠送积分活动 877842
科研通“疑难数据库(出版商)”最低求助积分说明 806595