Prognostic and clinicopathologic value of ki-67 and profilin 1 immunohistochemical expression in primary pT1 urothelial bladder cancer

膀胱癌 医学 免疫组织化学 癌症 内科学 生物标志物 Ki-67 肿瘤科 病理 原位癌 肿瘤进展 生物 生物化学
作者
Meftun Çulpan,Turgay Turan,Sıdıka Şeyma Özkanli,Tülay Zenginkinet,Özgür Kazan,Taha Uçar,Gökhan Atış,Turhan Çaşkurlu,Asıf Yıldırım
出处
期刊:Journal of Cancer Research and Therapeutics [BioMed Central]
卷期号:17 (2): 434-434 被引量:4
标识
DOI:10.4103/jcrt.jcrt_408_19
摘要

To investigate the prognostic and clinicopathologic value of Ki-67 and profilin 1 immunohistochemical expression in primary pT1 papillary urothelial bladder cancer.This study included 88 male and 13 female pT1 primary bladder cancer patients. Demographic characteristics, tumor histological grade, tumor number, presence of concomitant carcinoma in situ, tumor size, and status of recurrence or progression were recorded for each patient. Expression of Ki-67 and profilin 1 was evaluated by immunohistochemical analysis of paraffin-embedded tumor tissues. The Pearson's Chi-square test was used for the analysis of qualitative data, and the Kaplan-Meier method and the log-rank test were used for the survival analysis.In the mean follow-up period of 52 months, 52 (51.5%) patients experienced recurrence, 24 (23.8%) patients experienced progression, and 17 (16.8%) patients died from bladder cancer-related causes. Ki-67 expression was significantly associated with tumor histological grade (P = 0.001). In multivariate analysis, Ki-67 positivity had significantly worse outcome for recurrence (P = 0.006) and mortality (P = 0.022). Ki-67-positive (Ki-67 index ≥15%) patients had shorter recurrence-free (P = 0.003), progression-free (P = 0.002), and cancer-specific (P = 0.003) survival. However, no statistically significant relationship was found between profilin 1 expression and clinicopathologic features and prognosis.Ki-67 is a highly predictive biomarker for recurrence-free, progression-free, and cancer-specific survival in pT1 bladder cancer patients, in whom prediction of recurrence and progression are difficult. Ki-67 expression can be safely combined with other prognostic factors. However, in pT1 bladder cancer patients, no significant relationship was found between profilin 1 expression and tumor characteristics or prognostic parameters.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
大橙子发布了新的文献求助30
刚刚
丫头完成签到 ,获得积分10
1秒前
严西完成签到,获得积分10
2秒前
Mr.Ren完成签到,获得积分10
2秒前
Feng发布了新的文献求助10
3秒前
3秒前
skepticalsnails完成签到,获得积分0
4秒前
喜悦的向日葵完成签到,获得积分10
7秒前
纸柒完成签到 ,获得积分10
8秒前
9秒前
肖战战完成签到 ,获得积分10
10秒前
一一一应助songvv采纳,获得10
12秒前
量子星尘发布了新的文献求助10
12秒前
陶一二完成签到,获得积分10
13秒前
MM完成签到,获得积分10
14秒前
Who1990完成签到,获得积分10
15秒前
李友健完成签到 ,获得积分10
16秒前
hhhhh完成签到 ,获得积分10
18秒前
可耐的乘风完成签到,获得积分10
20秒前
wangnn发布了新的文献求助20
20秒前
大橙子发布了新的文献求助10
21秒前
21秒前
21秒前
余慵慵完成签到 ,获得积分10
22秒前
奋斗的小土豆完成签到,获得积分10
23秒前
ZJJ静完成签到,获得积分10
23秒前
邢大宝完成签到,获得积分10
24秒前
尔玉完成签到 ,获得积分10
26秒前
memo完成签到,获得积分10
26秒前
26秒前
一路芬芳完成签到,获得积分20
26秒前
28秒前
一一一应助songvv采纳,获得10
28秒前
28秒前
SciKid524完成签到 ,获得积分10
30秒前
科研通AI2S应助hhh采纳,获得10
30秒前
QWE完成签到,获得积分10
30秒前
赛赛完成签到 ,获得积分10
32秒前
tinydog完成签到,获得积分10
34秒前
长情琦完成签到,获得积分10
34秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022