Neural classification of internet gaming disorder and prediction of treatment response using a cue-reactivity fMRI task in young men

额上回 额中回 心理学 意识的神经相关物 缘上回 功能磁共振成像 免疫球蛋白D 额内侧回 舌回 神经科学 楔前 听力学 医学 认知 免疫学 B细胞 抗体
作者
Ziliang Wang,Marc N. Potenza,Kun‐Ru Song,Xiaoyi Fang,Lu Liu,Shan-Shan Ma,Cui‐Cui Xia,Jing Lan,Yuan‐Wei Yao,Jintao Zhang
出处
期刊:Journal of Psychiatric Research [Elsevier]
卷期号:145: 309-316 被引量:11
标识
DOI:10.1016/j.jpsychires.2020.11.014
摘要

Neural mechanisms underlying internet gaming disorder (IGD) are important for diagnostic considerations and treatment development. However, neurobiological underpinnings of IGD remain relatively poorly understood.We employed multi-voxel pattern analysis (MVPA), a machine-learning approach, to examine the potential of neural features to statistically predict IGD status and treatment outcome (percentage change in weekly gaming time) for IGD. Cue-reactivity fMRI-task data were collected from 40 male IGD subjects and 19 male healthy control (HC) subjects. 23 IGD subjects received 6 weeks of craving behavioral intervention (CBI) treatment. MVPA was applied to classify IGD subjects from HCs and statistically predict clinical outcomes.MVPA displayed a high (92.37%) accuracy (sensitivity of 90.00% and specificity of 94.74%) in the classification of IGD and HC subjects. The most discriminative brain regions that contribute to classification were the bilateral middle frontal gyrus, precuneus, and posterior lobe of the right cerebellum. MVPA statistically predicted clinical outcomes in the craving behavioral intervention (CBI) group (r = 0.48, p = 0.0032). The most strongly implicated brain regions in the prediction model were the right middle frontal gyrus, superior frontal gyrus, supramarginal gyrus, anterior/posterior lobes of the cerebellum and left postcentral gyrus.The findings about cue-reactivity neural correlates could help identify IGD subjects and predict CBI-related treatment outcomes provide mechanistic insight into IGD and its treatment and may help promote treatment development efforts.
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