潘顿-瓦伦丁杀白血病素
杀白素
金黄色葡萄球菌
微生物学
三级护理
耐甲氧西林金黄色葡萄球菌
生物
病毒学
医学
细菌
遗传学
家庭医学
作者
Meiji Soe Aung,Thida San,Noriko Urushibara,Nilar San,Win Mar Oo,Pan Ei Soe,Yamin Kyaw,Phyo May Ko,Pyae Phyo Thu,Myat Su Hlaing,Mitsuyo Kawaguchiya,Nobumichi Kobayashi
出处
期刊:Microbial Drug Resistance
[Mary Ann Liebert]
日期:2019-10-21
卷期号:26 (4): 360-367
被引量:15
标识
DOI:10.1089/mdr.2019.0208
摘要
Panton-Valentine leukocidin (PVL) is a pore-forming toxin encoded by genes on bacteriophages distributed to Staphylococcus aureus, associated with its increased virulence to humans. In this study, molecular epidemiological characteristics were investigated for 239 clinical isolates of S. aureus collected in a tertiary care hospital in Yangon, Myanmar, particularly with regard to methicillin resistance and PVL genes. Methicillin-resistant S. aureus (MRSA) accounted for 13.8% (33/239) and possessed mostly types IV- and V-SCCmec, while types III- and IX-SCCmec were identified in a few isolates. PVL genes were detected in 66.7% and 28.6% in MRSA and methicillin-susceptible S. aureus (MSSA), respectively. Among PVL-positive MRSA, ST772/SCCmec-V isolates (i.e., Bengal Bay clone) were predominant (73%, 16/22), and harbored PVL gene-encoding bacteriophage ΦSa119. Furthermore, two ST8-MRSA-SCCmec-IVa isolates harbored type-I arginine catabolic mobile element and ΦSa2usa: these isolates were considered the USA300 clone first identified in Myanmar. ΦPVL was the most frequent PVL phage among MSSA (56%, 33/59), and distributed to various genotypes, with ST88 and ST121 being dominant. In contrast, ΦSa2usa and ΦSa119 were also detected in MSSA with genotypes other than ST8 or ST772, suggesting the spread of these PVL phages to MSSA. The present study revealed potentially high prevalence of PVL phages among diverse clones of MRSA and MSSA in Myanmar.
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