化学
三氟甲磺酸
复分解
Knoevenagel冷凝
共价键
配体(生物化学)
金属
催化作用
组合化学
药物化学
有机化学
聚合
聚合物
生物化学
受体
作者
Ruirui Gu,Jean‐Maríe Lehn
标识
DOI:10.1002/asia.202001001
摘要
Abstract Knoevenagel barbiturate derivatives and imines are able to undergo efficient component recombination through dynamic covalent C=C/C=N organo‐metathesis in absence of a catalyst. A [2×2] dynamic covalent library (DCL) containing two Knoevenagel derivatives Kn1 and Kn2 and two imines A1 and A2 has been established and its adaptive features in response to the addition of metal cations have been investigated. Addition of Cu(I) triflate as an effector, induces fast and remarkable constitutional selection of the DCL towards amplification of the Cu(I)‐ A2 complex and its agonist Kn1 . This adaptation process could be reversed by addition of neocuproine as a competitive Cu(I) ligand. Furthermore, separate addition of five other metal cations as input agents, i. e. Ag(I), Fe(II), Zn(II), Cu(II) and Li(I), led to the generation of cation‐specific distribution patterns as outputs, showing the ability of the present DCL to recognize different effectors.
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