The toxicological impact of some agents on glutathione S-transferase and cholinesterase enzymes

In this chapter, we review the effects of some avermectins, benzimidazole, antibiotics, and other groups of agents on glutathione S-transferase (GST), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. The enzyme inhibition of these compounds can be expressed as the toxicological effect. GST is one of the enzymes responsible for the elimination of toxic molecules, and AChE and BChE are important markers of Alzheimer's disease (AD) and both enzymes are identified as cholinesterases. Experimental studies on inhibition revealed that the used drugs have significant inhibitory effects on GST, BChE, and AChE enzymes. The agents with the best inhibition and toxicological effects were determined for each enzyme. In order to observe the inhibition studies, first IC50 values were followed and Ki studies were performed to observe the toxicological effect of each enzyme with these agents.