姜黄素
丝素
脂质体
自愈水凝胶
细胞毒性
化学
药物输送
体外
癌细胞
控制释放
生物物理学
药理学
丝绸
材料科学
癌症
生物化学
医学
高分子化学
生物
有机化学
复合材料
内科学
作者
Chavee Laomeephol,Helena Ferreira,Sorada Kanokpanont,Nuno M. Neves,Hisatoshi Kobayashi,Siriporn Damrongsakkul
标识
DOI:10.1016/j.ijpharm.2020.119844
摘要
The administration of a drug-loaded implantable hydrogel at the tumor site after surgical resection is a viable approach to prevent the local recurrence or metastasis. Dimyristoyl glycerophosphorylglycerol (DMPG)-based liposomes were developed for inducing the rapid gelation of silk fibroin (SF) and delivering an anticancer drug, curcumin. Curcumin was loaded in the liposomes and the stability of curcumin was enhanced. The gelation time of liposome-induced SF hydrogels ranged from 3 min to more than 6 h. The biological activity of liposome-SF hydrogels was evaluated in vitro using L929 fibroblasts and MDA-MB-231 breast cancer cells. The release of curcumin can inhibit the growth of cancer cells. Both cells cultured on the surface of the hydrogels loaded with curcumin displayed low cell survival due to the combination of low cell attachment and cytotoxicity of curcumin. Liposome-SF hydrogels show potential as a sealant administered at the tumor site to eliminate residual cancer cells after tumor removal.
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