吞噬作用
吞噬体
吞噬小体
细胞生物学
内化
液泡
生物
受体
传出细胞增多
内吞作用
巨噬细胞
化学
体外
生物化学
细胞质
作者
Eileen Uribe‐Querol,Carlos Rosales
标识
DOI:10.3389/fimmu.2020.01066
摘要
Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 micrometer in diameter, including microorganisms, foreign substances, and apoptotic cells. Phagocytosis is found in many types of cells and it is, in consequence an essential process for tissue homeostasis. However, only specialized cells termed professional phagocytes accomplish phagocytosis with high efficiency. Macrophages, neutrophils, monocytes, dendritic cells, and osteoclasts are among these dedicated cells. These professional phagocytes express several phagocytic receptors that activate signaling pathways resulting in phagocytosis. The process of phagocytosis involves several phases: i) detection of the particle to be ingested, ii) activation of the internalization process, iii) formation of a specialized vacuole called phagosome, and iv) maturation of the phagosome to transform it into a phagolysosome. In this review, we present a general view of our current understanding on cells, phagocytic receptors and phases involved in phagocytosis.
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