Oxadiazepine Synthesis by Formal [4+3] Cycloaddition of o‐Chloromethyl Arylsulfonamides with Nitrones Promoted by NaHCO3

Abstract An effective and facile method for the synthesis of highly substituted 1,2,3,5‐tetrahydrobenzo[ e ][1,2,4]‐oxadiazepines is described. A formal [4+3] cycloaddition of N ‐(2‐(chloromethyl) phenyl) amides with nitrones afforded benzo[ e ][1,2,4]‐oxadiazepine derivatives with high atom economy and excellent yields (up to 97%). magnified image