亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice

内分泌学 发病机制 内科学 糖尿病 硫辛酸 2型糖尿病 医学 生物 化学 生物化学 抗氧化剂
作者
Ting Gao,Shengnan Qian,Shuang Shen,Xiaoying Zhang,Junli Liu,Weiping Jia,Zhong Chen,Jianping Ye
出处
期刊:Biochemical and Biophysical Research Communications [Elsevier]
卷期号:512 (1): 106-111 被引量:16
标识
DOI:10.1016/j.bbrc.2019.02.155
摘要

LA (alpha-Lipoic acid) deficiency represents a risk factor in the pathogenesis of diabetic complications as synthetic LA is routinely used in the treatment of the complications in patients. The mechanism underlying LA deficiency remains elusive in the diabetic conditions. In the present study, we investigated the synthetic pathway of LA in both type 1 and 2 diabetic mice. LA deficiency was observed with a reduction in lipoylation of pyruvate dehydrogenase in the kidney of streptozocin-induced diabetic mice. Proteins of three enzymes (MCAT, OXSM and LIAS) in the LA synthetic pathway were examined in the kidney. A reduction was observed in OXSM, but not in the other two. In a 24h study in the cell culture, mRNA and protein of OXSM were transiently reduced by a high concentration of glucose (35 mM), and persistently decreased by TNF-α (20 nM). The high glucose effect was observed with the OXSM reduction in the kidney of db/db mice (type 2 diabetes model). The TNF-α effect was observed with OXSM reduction in the fat tissue of diet-induced obese mice. The result suggest that inhibition of OXSM by hyperglycemia and inflammation may contribute to the LA deficiency in the diabetic complications. The OXSM reduction suggests a new mechanism for the mitochondrial dysfunction in the pathogenesis of diabetic complications.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
郜雨寒发布了新的文献求助10
4秒前
kk_1315完成签到,获得积分10
16秒前
17秒前
Lonala完成签到,获得积分10
18秒前
20秒前
28秒前
000完成签到 ,获得积分10
30秒前
小鸟芋圆露露完成签到 ,获得积分10
32秒前
Nakacoke77完成签到,获得积分10
38秒前
49秒前
52秒前
科研通AI2S应助科研通管家采纳,获得10
55秒前
木头人呐完成签到 ,获得积分10
57秒前
鹅鹅鹅发布了新的文献求助10
58秒前
59秒前
嘤嘤怪完成签到 ,获得积分10
1分钟前
1分钟前
迟暮完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
mokmok发布了新的文献求助10
1分钟前
1分钟前
1分钟前
yema完成签到,获得积分10
1分钟前
1分钟前
1分钟前
草莓熊1215完成签到 ,获得积分10
1分钟前
1分钟前
樱桃猴子应助Rita采纳,获得10
1分钟前
我是老大应助研友_Z3NGvn采纳,获得10
1分钟前
花玥鹿完成签到,获得积分10
1分钟前
1分钟前
HELAOBAN发布了新的文献求助10
2分钟前
2分钟前
Jay发布了新的文献求助10
2分钟前
2分钟前
鹅鹅鹅完成签到,获得积分10
2分钟前
blue2021发布了新的文献求助10
2分钟前
希望天下0贩的0应助HELAOBAN采纳,获得10
2分钟前
深情安青应助Sherry采纳,获得10
2分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196601
求助须知:如何正确求助?哪些是违规求助? 2845351
关于积分的说明 8053943
捐赠科研通 2509944
什么是DOI,文献DOI怎么找? 1342121
科研通“疑难数据库(出版商)”最低求助积分说明 639320
邀请新用户注册赠送积分活动 608622