Pd-catalyzed Cyclization of Terminal Alkynes using Diazonaphthoquinones: Synthesis of Naphtho[1,2-b]furans

Naphtho [1,2-b]furans were synthesized via a Pd-1 catalyzed reaction of diazonaphthoquinones and terminal 2 alkynes in the presence of CuI and diisopropylamine.This 3 method was then successfully applied to the synthesis of 4 natural product, furomollugin.5