间充质干细胞
旁分泌信号
微泡
胞外囊泡
脐带
细胞生物学
细胞
癌症研究
干细胞
免疫原性
医学
细胞疗法
干细胞疗法
小RNA
生物
免疫学
免疫系统
内科学
受体
基因
生物化学
遗传学
作者
Hossein Abbaszadeh,Farzaneh Ghorbani,Mehdi Derakhshani,Ali Akbar Movassaghpour,Mehdi Yousefi
摘要
Abstract Mesenchymal stem cells (MSCs) have been revealed to hold great potential for the development of new treatment approaches for various diseases. However, the clinical use of these cells is limited due to their tumorigenic effects. The therapeutic benefits of MSCs are largely dependent on paracrine factors including extracellular vesicles (EVs). EVs are nano‐sized bilayer membrane structures containing lipids, microRNAs and proteins which play key roles in cell‐to‐cell communications. Because of their lower immunogenicity, tumorigenicity, and easier management, EVs have emerged as a new promising alternative to whole‐cell therapy. Therefore, this paper reviews current preclinical studies on the use of EVs derived from human umbilical cord MSCs (hucMSCs) as a therapeutic approach in treatment of several diseases including neurological, cardiovascular, liver, kidney, and bone diseases as well as the cutaneous wound, inflammatory bowel disease, cancers, infertility, and other disorders.
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