姜黄素
胶束
聚乙二醇
体内
鼻腔给药
血脑屏障
Zeta电位
渗透(战争)
药理学
化学
材料科学
药物输送
纳米技术
纳米颗粒
生物物理学
有机化学
医学
水溶液
生物技术
内分泌学
工程类
中枢神经系统
生物
运筹学
作者
P. Rajiv Prasad Keshari,Yogesh A. Sonar,Hitendra S. Mahajan
标识
DOI:10.1080/10667857.2019.1575535
摘要
The effective treatment of brain cancer is hindered by the poor transport across the blood-brain barrier (BBB) and the low penetration across the blood-tumour barrier (BTB). The main objective of this work was to the development of stable micelles of curcumin which may enhance the brain targeting of CRM via intranasal administration. Curcumin-loaded D-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS) micelles were prepared by thin film hydration method and characterized for their particle sizes and zeta potential. The morphological study was done by transmission electron microscopy. The particle sizes of the curcumin-loaded targeted micelles were 146.8 nm. About 98.19 ± 1.2% of drug encapsulation efficiency was achieved with micelles. The in vivo study results indicated that curcumin loaded TPGS micelles could be a promising carrier for brain targeting in comparison to the non-targeted micelles.
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