医学
牙龈卟啉单胞菌
关节炎
免疫学
类风湿性关节炎
炎性关节炎
牙周炎
牙龈炎
炎症
内科学
促炎细胞因子
牙科
作者
Guillaume Courbon,Mélanie Rinaudo-Gaujous,Vincent Blasco‐Baque,Isabelle Auger,Robin Caire,Lambert Mijola,Laurence Vico,Stéphane Paul,Hubert Marotte
标识
DOI:10.1136/annrheumdis-2018-213697
摘要
Objectives Association between periodontal disease (PD) and rheumatoid arthritis (RA) has been extensively described, but direct evidence of causal involvement of PD in RA is missing. We investigated the priming role of oral Porphyromonas gingivalis ( P. gingivalis ) in PD and subsequent RA and we assessed biomarkers of bone resorption and arthritis development in rats. Methods Lewis rats were orally exposed to either P. gingivalis , Prevotella intermedia or control gel for 1 month and then followed for 8 months. The onset and development of PD was assessed by serology, gingivitis severity and micro-CT (µCT). We investigated arthritis development using circulating proinflammatory markers, anticyclic citrullinated peptide (CCP), anticitrullinated protein antibody (ACPA), ankle histology and µCT. Results PD was only observed in the P. gingivalis treated rats, as early as 1 month postexposure. Joint and systemic inflammation were detected only in the P. gingivalis group after 4 and 8 months. At 8 months, inflammatory cell infiltrate was observed in ankle joints and paralleled cortical erosions and overall cortical bone reduction. Furthermore, anti-CCP2 correlated with local and systemic bone loss. Conclusions In our long-term study, PD induced by oral exposure to P. gingivalis triggered seropositive arthritis, with systemic inflammation and bone erosions. This is the first in vivo demonstration of arthritis induced by oral priming with P. gingivalis .
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