The clinical value of D-dimer/fibrinogen ratio and hypersensitive C-reactive protein in patients with acute coronary syndromes

Objective 　To analyze the correlation between D-dimer/fibrinogen (D/F) ratio, hypersensitive C-reactive protein (hs-CRP) level and the severity of coronary stenosis and illness in patients with acute coronary syndrome (ACS), and explore the clinical application value of D/F ratio. Methods 　The case data of 443 patients undergone coronary angiography in the Department of Cardiology, Nanfang Hospital, Southern Medical University during Jan. 2014 to Dec. 2017 were collected, and then the patients were divided into normal group, stable angina pectoris (SAP) group and acute coronary syndrome (ACS) group. The ACS group was divided into single-vessel disease group, double-vessel disease group and triple-vessel disease group according to the number of coronary lesions and into high Gensini score group and low Gensini score group according to the median of Gensini score. The correlations of D-dimer, fibrinogen, D/F ratio and hs-CRP with ACS were compared respectively, and then analyzing the predictive value for diagnosis of ACS and evaluation of lesion severity. Results 　The overall trend of D-dimer, fibrinogen and hs- CRP was normal group 0.05). Multivariate logistic regression analysis revealed that D/F ratio and hs-CRP were independent risk factors for high Gensini score in ACS patients (OR=1.136, P=0.045; OR=1.197, P<0.001). Conclusion 　D/F ratio and hs-CRP were significantly associated to the severity of coronary lesion, and were the independent risk factors for high Gensini score in patients with ACS. DOI: 10.11855/j.issn.0577-7402.2018.11.07