血管生成
转移
癌症研究
肿瘤微环境
医学
肿瘤进展
癌症
肿瘤细胞
内科学
作者
Arash Salmaninejad,Saeed Farajzadeh Valilou,Arash Soltani,Sepideh Ahmadi,Yousef Jafari Abarghan,Khaled Greish,Amirhossein Sahebkar
标识
DOI:10.1007/s13402-019-00453-z
摘要
Tumor-associated macrophages (TAMs) are known to play important roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs are considered as main components of the tumor microenvironment. Targeting TAMs may serve as a therapeutic strategy for the treatment of cancer. In this review, the signaling pathways, origin, function, polarization and clinical application of TAMs are discussed. The role of TAMs in tumor initiation, progression, angiogenesis, invasion and metastasis are also emphasized. In addition, a variety of clinical and pre-clinical approaches to target TAMs are discussed. Clinical therapeutic approaches that show most promise include blocking the extravasation of TAMs along with using TAMs as diagnostic biomarkers for cancer progression. The targeting of TAMs in a variety of clinical settings appears to be a promising strategy for decreasing metastasis formation and for improving patient outcome.
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