起始因子
蛋白质生物合成
生物
翻译(生物学)
EIF4EBP1型
EIF4A1
细胞生物学
真核起始因子
真核翻译
信使核糖核酸
真核生物翻译延伸因子1α1
真核生物γ翻译起始因子4
遗传学
核糖核酸
基因
核糖体
作者
Dieter A Wolf,Yingying Lin,Haoran Duan,Yabin Cheng
摘要
Abstract Studies over the past three years have substantially expanded the involvements of eukaryotic initiation factor 3 (eIF3) in messenger RNA (mRNA) translation. It now appears that this multi-subunit complex is involved in every possible form of mRNA translation, controlling every step of protein synthesis from initiation to elongation, termination, and quality control in positive as well as negative fashion. Through the study of eIF3, we are beginning to appreciate protein synthesis as a highly integrated process coordinating protein production with protein folding, subcellular targeting, and degradation. At the same time, eIF3 subunits appear to have specific functions that probably vary between different tissues and individual cells. Considering the broad functions of eIF3 in protein homeostasis, it comes as little surprise that eIF3 is increasingly implicated in major human diseases and first attempts at therapeutically targeting eIF3 have been undertaken. Much remains to be learned, however, about subunit- and tissue-specific functions of eIF3 in protein synthesis and disease and their regulation by environmental conditions and post-translational modifications.
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