ChemInform Abstract: The Role of Reversible Oxidative Addition in Selective Palladium(0)‐Catalyzed Intramolecular Cross‐Couplings of Polyhalogenated Substrates: Synthesis of Brominated Indoles.

Abstract The synthesis of brominated indoles such as (II) is shown to proceed only in the presence of the bulky P(tBu) 3 ligand; other ligands such as PPh 3 , SPhos, JohnPhos, BINAP, PCy 3 , dppf, P(o‐Tol) 3 , or xantphos give only trace amounts of indole products (<5%).