磷酸西他列汀
化学
三氟甲基
钥匙(锁)
组合化学
磷酸西他列汀
二肽基肽酶-4抑制剂
二肽基肽酶
可扩展性
生物化学
有机化学
内分泌学
计算机科学
数据库
糖尿病
酶
2型糖尿病
医学
烷基
计算机安全
作者
Lakshmikant H. Nitlikar,Sunil N. Darandale,Devanand B. Shinde
出处
期刊:Letters in Organic Chemistry
[Bentham Science]
日期:2013-05-01
卷期号:10 (5): 348-352
被引量:10
标识
DOI:10.2174/1570178611310050008
摘要
The practical synthesis of 3-(trifluoromethyl)-triazolopiperazine the key intermediate of Sitagliptin and 3- (trifluoromethyl)-triazolopyridine was carried out employing industrially feasible transformations. The other advantage of this method is the new environment friendly approach to synthesize triazolopiperazine and triazolopyridines by eliminating the commonly used trifluoroacetic anhydride and polyphosphoric acid. Keywords: Sitagliptin, 3-(trifluoromethyl)-triazolopiperazine, 3-(trifluoromethyl)-triazolopyridine, antidiabetic.
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