Synthesis and biological evaluation of some new 2,5-disubstituted 1,3,4-oxadiazoles from 3-(arylsulfonyl) propanehydrazides

Methyl acrylate on treatment with aryl thiols gives methyl 3-(arylthio) propanoates. The latter on oxidation with hydrogen peroxide followed by reaction with hydrazine hydrate gives 3-(arylsulfonyl) propanehydrazides. Two new series of 2,5-disubstituted-1,3,4-oxadiazoles from 3-[(4-chlorophenyl)sulfonyl] propane hydrazide and 3-[(4-methylphenyl)sulfonyl] propane hydrazide have been synthesized and tested for antimicrobial activities. Some of these compounds have shown good antimicrobial activity.