Iatrogenic peripheral nerve injury is a considerable social and economic concern and the majority of cases are preventable. Complications should be referred to, and dealt with promptly by experienced surgeons, to ensure the best chances for an optimal functional recovery. Their prevention should be emphasized. Their management should include ensuring an early diagnosis, administering an appropriate treatment with rehabilitation, rendering psychological support and providing control of pain. We will address the aetiology, predisposing factors, diagnostic approaches, and management strategies to reduce the incidence of iatrogenic peripheral nerve injuries.