组织工程
介孔二氧化硅
纳米医学
纳米技术
药物输送
纳米颗粒
材料科学
纳米载体
生物医学工程
介孔材料
工程类
化学
生物化学
催化作用
作者
Liang Chen,Xiaojun Zhou,Chuanglong He
摘要
Abstract Mesoporous silica nanoparticles (MSNs) have been widely investigated as a nanocarrier for the delivery of various cargoes in nanomedicine. The application of MSNs in tissue engineering is a relatively newly emerged field that has gained much research interest. In this review, the recent advances in the tissue‐engineering application of MSNs are summarized. The controlled synthesis of MSNs is delineated first in terms of tuning the morphology, pore size of MSNs, and its surface chemistry, as well as biodegradability. Then, the different roles of MSNs in tissue engineering are successively introduced, which mainly comprise the delivery of bioactive factors, the inherent bioactivity of MSNs, stem cells labelling, and the impacts of incorporated MSNs on scaffolds. Furthermore, the recent progress in the applications of MSNs for tissue engineering, particularly bone tissue engineering, is summarized in detail. Finally, the challenges or potential trends for the further applications of MSNs in tissue engineering are also discussed. This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Implantable Materials and Surgical Technologies > Nanomaterials and Implants
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