抗菌活性
化学
金黄色葡萄球菌
钋
细菌
大肠杆菌
聚合物
组合化学
烷基
革兰氏阳性菌
抗菌剂
有机化学
抗生素
生物化学
生物
基因
遗传学
作者
Tyler J. Cuthbert,Benjamin Hisey,Tristan D. Harrison,John F. Trant,Elizabeth R. Gillies,Paul J. Ragogna
标识
DOI:10.1002/anie.201806412
摘要
Abstract There is currently an urgent need for the development of new antibacterial agents to combat the spread of antibiotic‐resistant bacteria. We explored the synthesis and antibacterial activities of novel, sugar‐functionalized phosphonium polymers. While these compounds exhibited antibacterial activity, we unexpectedly found that the control polymer poly(tris(hydroxypropyl)vinylbenzylphosphonium chloride) showed very high activity against both Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus and very low haemolytic activity against red blood cells. These results challenge the conventional wisdom in the field that lipophilic alkyl substituents are required for high antibacterial activity and opens prospects for new classes of antibacterial polymers.
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