紫苏
唇形科
脂多糖
紫苏
传统医学
化学
生物碱
草本植物
立体化学
生物
生物化学
草药
医学
免疫学
有机化学
原材料
作者
Xiaofeng Wang,Heng Li,Kun Jiang,Qiqi Wang,Yanhai Zheng,Wei Tang,Chang‐Heng Tan
出处
期刊:Fitoterapia
[Elsevier]
日期:2018-10-01
卷期号:130: 61-65
被引量:44
标识
DOI:10.1016/j.fitote.2018.08.006
摘要
Perilla frutescens (L.) Britt. (Lamiaceae) is a traditionally medicinal herb in East Asian countries to treat various diseases. In present study, the low-polarity constituents of the aerial parts of P. frutescens were investigated and their anti-inflammatory effect on lipopolysaccharide (LPS)-stimulated RAW264.7 cells were assayed. Three new furanoid monoterpenoids, named as frutescenones A - C (1-3), together with thirteen known compounds (4-16) were isolated and identified on the basis of extensive spectroscopic analysis and a single-crystal X-ray diffraction study. Among these components, 1 is an unusual monoterpenoid with 2,3'-bifuran skeleton, and 3 is a rare perillaketone-adenine hybrid heterodimer, while the revised NMR arrangements of 4 were reported at the first time. Furthermore, monoterpenoid 4 and alkaloid 15 showed remarkably inhibitory effect on the production of inflammatory mediator (NO) and pro-inflammatory cytokines (TNF-α and/or IL-6) in LPS-stimulated RAW264.7 cells.
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