加巴能
神经科学
生物
星形胶质细胞
神经传递
细胞内
中间神经元
γ-氨基丁酸
抑制性突触后电位
中枢神经系统
细胞生物学
受体
生物化学
作者
Annamaria Lia,Micaela Zonta,Linda Maria Requie,Giorgio Carmignoto
标识
DOI:10.1016/j.neulet.2018.06.026
摘要
• Astrocytes respond to GABAergic signal with increases in the intracellular Ca 2+ concentration. • GABA-activated astrocytes release gliotransmitters that modulate neuronal activity • Astrocytes can influence GABAergic transmission. • The interplay between GABAergic interneurons and astrocytes is relevant for brain physiology and pathology. Brain network activity derives from the concerted action of different cell populations. Together with interneurons, astrocytes play fundamental roles in shaping the inhibition in brain circuitries and modulating neuronal transmission. In this review, we summarize past and recent findings that reveal in neural networks the importance of the interaction between GABAergic signaling and astrocytes and discuss its physiological and pathological relevance.
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