免疫
免疫系统
昼夜节律
生物钟
生物
神经科学
免疫学
作者
Kevin Man,Andrew Loudon,Ajay Chawla
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-11-25
卷期号:354 (6315): 999-1003
被引量:240
标识
DOI:10.1126/science.aah4966
摘要
Immunity is a high-cost, high-benefit trait that defends against pathogens and noxious stimuli but whose overactivation can result in immunopathologies and sometimes even death. Because many immune parameters oscillate rhythmically with the time of day, the circadian clock has emerged as an important gatekeeper for reducing immunity-associated costs, which, in turn, enhances organismal fitness. This is mediated by interactions between extrinsic environmental cues and the intrinsic oscillators of immune cells, which together optimize immune responses throughout the circadian cycle. The elucidation of these clock-controlled immunomodulatory mechanisms might uncover new approaches for treating infections and chronic inflammatory diseases.
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