胶质瘤
埃罗替尼
癌症研究
亲脂性
细胞毒性T细胞
表皮生长因子受体
靶向治疗
癌细胞
化学
细胞毒性
体外
癌症
生物
生物化学
受体
遗传学
作者
Marcos Couto,Ignacio Mastandrea,Mauricio Cabrera,Pablo Cabral,Francesç Teixidor,Hugo Cerecetto,Clara Viñas
标识
DOI:10.1002/chem.201701965
摘要
Abstract The reported new anilinoquinazoline‐icosahedral borane hybrids have been evaluated as glioma targeting for potential use in cancer therapy. Their anti ‐glioma activity depends on hybrids’ lipophilicity; the most powerful compound against glioma cells, a 1,7‐ closo ‐derivative, displayed at least 3.3 times higher activity than the parent drug erlotinib. According to the cytotoxic effects on normal glia cells, the hybrids were selective for epidermal growth factor receptor (EGFR)‐overexpressed tumor cells. These boron carriers could be used to enrich glioma cancer cells with boron for cancer therapy.
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