Double Metal Co-Doping of TiO2 Nanoparticles for Improvement of their SERS Activity and Ultrasensitive Detection of Enrofloxacin: Regulation Strategy of Energy Levels

ChemistrySelectVolume 2, Issue 10 p. 3099-3105 Full Paper Double Metal Co–Doping of TiO2 Nanoparticles for Improvement of their SERS Activity and Ultrasensitive Detection of Enrofloxacin: Regulation Strategy of Energy Levels Dr. Xin Jiang, Dr. Xin Jiang College of Pharmacy, Jiamusi University, Jiamusi, 154007 P.R. China These authors made equal contributions to this work.Search for more papers by this authorKun Song, Kun Song College of Pharmacy, Jiamusi University, Jiamusi, 154007 P.R. China These authors made equal contributions to this work.Search for more papers by this authorXiuling Li, Xiuling Li College of Pharmacy, Jiamusi University, Jiamusi, 154007 P.R. ChinaSearch for more papers by this authorMing Yang, Ming Yang College of Pharmacy, Jiamusi University, Jiamusi, 154007 P.R. ChinaSearch for more papers by this authorDr. Xiaoxia Han, Dr. Xiaoxia Han State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012 P.R. ChinaSearch for more papers by this authorProf. Libin Yang, Corresponding Author Prof. Libin Yang ylb76@163.com College of Pharmacy, Jiamusi University, Jiamusi, 154007 P.R. ChinaSearch for more papers by this authorProf. Bing Zhao, Corresponding Author Prof. Bing Zhao zhaob@mail.jlu.edu.cn State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012 P.R. ChinaSearch for more papers by this author Dr. Xin Jiang, Dr. Xin Jiang College of Pharmacy, Jiamusi University, Jiamusi, 154007 P.R. China These authors made equal contributions to this work.Search for more papers by this authorKun Song, Kun Song College of Pharmacy, Jiamusi University, Jiamusi, 154007 P.R. China These authors made equal contributions to this work.Search for more papers by this authorXiuling Li, Xiuling Li College of Pharmacy, Jiamusi University, Jiamusi, 154007 P.R. ChinaSearch for more papers by this authorMing Yang, Ming Yang College of Pharmacy, Jiamusi University, Jiamusi, 154007 P.R. ChinaSearch for more papers by this authorDr. Xiaoxia Han, Dr. Xiaoxia Han State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012 P.R. ChinaSearch for more papers by this authorProf. Libin Yang, Corresponding Author Prof. Libin Yang ylb76@163.com College of Pharmacy, Jiamusi University, Jiamusi, 154007 P.R. ChinaSearch for more papers by this authorProf. Bing Zhao, Corresponding Author Prof. Bing Zhao zhaob@mail.jlu.edu.cn State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012 P.R. ChinaSearch for more papers by this author First published: 11 April 2017 https://doi.org/10.1002/slct.201700099Citations: 13 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract The strategy of double metals codoping was carried out for improving SERS activity of TiO2 nanoparticles for the first time, and the double metals codoped TiO2 was firstly served as SERS-active substrate for ultrasensitive detection of enrofloxacin drug molecules. Abstract In this paper, the strategy of double metals (Ni and Zn) codoping was carried out for improving SERS activity of TiO2 nanoparticles (NPs). Accordingly, pure TiO2 and different metals doped TiO2 (Zn-TiO2, Ni-TiO2 and Ni−Zn-TiO2) NPs substrates were synthesized by a sol-hydrothermal method. The results show that, compared to the other substrates, 4-mercaptobenzoic acid (4-MBA) probe molecules on the Ni−Zn-TiO2 exhibit the largest SERS enhancement, which is attributed to the contributions of double metals codoping. Ni and Zn codoping can simultaneously result in the abundant surface state levels and metal doping levels in the TiO2 band gap; both of them together promote the charge transfer from TiO2 to molecule and consequent SERS enhancement of probe molecule. And importantly, Ni−Zn-TiO2 NPs can be served as the efficient SERS-active substrate for the detection of enrofloxacin (ENR) drug. Under the optimal test conditions, the limit of detection of ENR on the 1 %Ni-1 %Zn-TiO2 substrate can be reduced to 3×10−10 M, which is far lower than the standard of European Union, and there is a good linear relationship in the wide low concentration range of 1×10−4∼1×10−9 M. Conflict of interest The authors declare no conflict of interest. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description slct201700099-sup-0001-misc_information.pdf228.3 KB Supplementary Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume2, Issue10April 3, 2017Pages 3099-3105 RelatedInformation