生物材料
体内
粘附
生物膜
材料科学
吞噬作用
金黄色葡萄球菌
巨噬细胞
先天免疫系统
免疫系统
胶囊
生物医学工程
微生物学
体外
免疫学
纳米技术
细菌
医学
化学
生物
复合材料
生物技术
植物
生物化学
遗传学
作者
Jiaxuan Chen,Caitlin Howell,Carolyn A. Haller,Madhukar S. Patel,Perla Ayala,Katherine A. Moravec,Erbin Dai,Liying Liu,Irini Sotiri,Michael Aizenberg,Joanna Aizenberg,Elliot L. Chaikof
出处
期刊:Biomaterials
[Elsevier]
日期:2016-10-06
卷期号:113: 80-92
被引量:107
标识
DOI:10.1016/j.biomaterials.2016.09.028
摘要
Virtually all biomaterials are susceptible to biofilm formation and, as a consequence, device-associated infection. The concept of an immobilized liquid surface, termed slippery liquid-infused porous surfaces (SLIPS), represents a new framework for creating a stable, dynamic, omniphobic surface that displays ultralow adhesion and limits bacterial biofilm formation. A widely used biomaterial in clinical care, expanded polytetrafluoroethylene (ePTFE), infused with various perfluorocarbon liquids generated SLIPS surfaces that exhibited a 99% reduction in S. aureus adhesion with preservation of macrophage viability, phagocytosis, and bactericidal function. Notably, SLIPS modification of ePTFE prevents device infection after S. aureus challenge in vivo, while eliciting a significantly attenuated innate immune response. SLIPS-modified implants also decrease macrophage inflammatory cytokine expression in vitro, which likely contributed to the presence of a thinner fibrous capsule in the absence of bacterial challenge. SLIPS is an easily implementable technology that provides a promising approach to substantially reduce the risk of device infection and associated patient morbidity, as well as health care costs.
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