材料科学
纳米技术
乳状液
均质化(气候)
分子
双水相体系
纳米结构
制作
化学工程
水溶液
化学
有机化学
工程类
生物多样性
病理
生物
医学
替代医学
生态学
作者
Shukai Ding,Nicolas Anton,Salman Akram,Meriem Er‐Rafik,Halina Anton,Andrey S. Klymchenko,Wei Yu,Thierry Vandamme,Christophe A. Serra
出处
期刊:Soft Matter
[The Royal Society of Chemistry]
日期:2017-01-01
卷期号:13 (8): 1660-1669
被引量:30
摘要
Double emulsions are very attractive systems for many reasons; the most important of these are their capacity to encapsulate hydrophilic and lipophilic molecules simultaneously in a single particle and their potentiality to protect fragile hydrophilic molecules from the continuous phase. Double emulsions represent a technology that is widely present down to the micrometer scale; however, double nanoemulsions, with their new potential applications as nanomedicines or diagnosis agents, currently present a significant challenge. In this study, we propose an original two-step approach for the fabrication of double nanoemulsions with a final size below 200 nm. The process consists of the formulation of a primary water-in-oil (w1/O) nanoemulsion by high-pressure homogenization, followed by the re-emulsification of this primary emulsion by a low-energy method to preserve the double nanostructure. Various characterization techniques were undertaken to confirm the double structure and to evaluate the encapsulation efficiency of a small hydrophilic probe in the inner aqueous droplets. Complementary fluorescence confocal and cryo-TEM microscopy experiments were conducted to characterize and confirm the double structure of the double nanoemulsion.
科研通智能强力驱动
Strongly Powered by AbleSci AI