医学
冲程(发动机)
再灌注治疗
闭塞
再灌注损伤
缺血性中风
缺血
心脏病学
内科学
机械工程
工程类
作者
Ximing Nie,Xinyi Leng,Zhongrong Miao,Marc Fisher,Liping Liu
出处
期刊:Stroke
[Ovid Technologies (Wolters Kluwer)]
日期:2023-03-01
卷期号:54 (3): 873-881
被引量:47
标识
DOI:10.1161/strokeaha.122.038466
摘要
Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large vessel occlusion. However, in clinical practice, nearly half of the patients do not have favorable outcomes despite successful recanalization of the occluded artery. This unfavorable outcome can be defined as having clinically ineffective reperfusion. The objective of the review is to describe clinically ineffective reperfusion after endovascular therapy and its underlying risk factors and mechanisms, including initial tissue damage, cerebral edema, the no-reflow phenomenon, reperfusion injury, procedural features, and variations in postprocedural management. Further research is needed to more accurately identify patients at a high risk of clinically ineffective reperfusion after endovascular therapy and to improve individualized periprocedural management strategies, to increase the chance of achieving favorable clinical outcomes.
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