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Brain-Derived Neurotrophic Factor Regulates Differentiation of Stem Cells From Human Exfoliated Deciduous Teeth Through Growth Factor Receptor-Bound Protein 2-Extracellular Signal-Regulated Kinase Signaling Pathway

神经营养因子 细胞生物学 生物 干细胞 神经干细胞 脑源性神经营养因子 低亲和力神经生长因子受体 信号转导 细胞分化 神经营养素 受体 生物化学 基因
作者
Wei Wang,Qingwen Liu,Yuefei Zou
出处
期刊:Experimental and Clinical Transplantation [Baskent University Publishers]
卷期号:20 (11): 1016-1021
标识
DOI:10.6002/ect.2022.0185
摘要

Stem cells from human exfoliated deciduous teeth are a population of multipotent mesenchymal stem cells that can self-renew and actively secrete a broad spectrum of trophic and immunomodulatory factors.Brain-derivedneurotrophic factor is able to induce stem cells to neural differentiation to repair the nervous system. However,the mechanism ofbrain-derivedneurotrophic factor-induced neural differentiation in stem cells from human exfoliated deciduous teeth remains unclear.In this study, we focused on brain-derived neurotrophic factor and investigated its effects on neural differentiation in stem cells from human exfoliated deciduous teeth. We cultured stem cells from human exfoliated deciduous teeth under various different brain-derived neurotrophic factor concentrations. We then analyzed the effects of brain-derived neurotrophic factor to the neural differen-tiation and associated signaling pathways in stem cells from human exfoliated deciduous teeth.We demonstrated that a high concentration of brain-derived neurotrophic factor could induce neural differentiation in stem cells from human exfoliated deciduous teeth, and brain-derived neurotrophic factor also increased the expression levels of neural differentiation-related proteins in stem cells from human exfoliated deciduous teeth, which was associated with the suppression of growth factor receptor-bound protein 2/extracellular signal-regulated kinase 1 and 2 signaling pathways.Knockdown of growth factor receptor- bound protein 2 inhibited the neural differentiation of stem cells from human exfoliated deciduous teeth via changes in growth factor receptor-bound protein 2/extracellular signal-regulated kinase signaling pathways, but this phenotype could be rescued by overexpression of extracellular signal-regulated kinase. Our findings suggested that brain-derived neurotrophic factor can regulate the differentiation of stem cells from human exfoliated deciduous teeth through the growth factor receptor-bound protein 2/extracellular signal-regulated kinase signaling pathway.

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