Factors associated with lower disease‐specific and generic health‐related quality of life in Rome IV irritable bowel syndrome

Summary Background Little is known about associations with reduced quality of life in irritable bowel syndrome (IBS) or impact of IBS on quality of life compared with other chronic conditions. Methods We collected demographic, gastrointestinal and psychological symptoms, healthcare usage, direct healthcare costs, impact on work and activities of daily living data from 752 individuals with Rome IV‐defined IBS. We used the irritable bowel syndrome quality of life (IBS‐QOL) and the EQ‐5D‐5L questionnaires to examine characteristics associated with lower quality of life. Results The mean IBS‐QOL among all 752 individuals with Rome IV IBS was 48.4 (SD 22.3) and the mean EQ‐5D score was 0.570 (SD 0.283), the latter being comparable to people with stroke, leg ulcers or chronic obstructive pulmonary disease. Lower levels of both disease‐specific and generic quality of life were associated with severe IBS symptom scores, abnormal anxiety or depression scores, and higher somatoform symptom‐reporting and gastrointestinal symptom‐specific anxiety scores ( p < 0.001 for all analyses). Those with lower quality of life had significantly higher healthcare usage and direct healthcare costs and more impairment in work and activities of daily living ( p < 0.01 for all analyses). Avoidance of alcohol, lower educational level, abnormal anxiety, depression or somatoform symptom‐reporting scores, and impairment in social leisure activities, home management or maintaining close relationships were all independently associated with lower quality of life. Conclusion IBS has a substantial impact on the quality of life of those affected, and worse than observed in some severe chronic organic conditions.