Investigating immune responses to Harmful Algal Bloom cyanotoxins in protection of human health and the environment

趋化因子 免疫系统 生物 水华 炎症 免疫学 生态学 浮游植物 营养物
作者
Swinburne A. J. Augustine,Michelle Catherine Robillard,Armah De la Cruz
出处
期刊:Journal of Immunology [The American Association of Immunologists]
卷期号:208 (1_Supplement): 46.01-46.01 被引量:1
标识
DOI:10.4049/jimmunol.208.supp.46.01
摘要

Abstract Harmful algal blooms (HABs) are a major environmental and public health concern globally that impact multiple essential areas including agriculture, drinking water, and recreational water. Although harmful blooms are caused by other organisms, those from cyanobacteria are the most common freshwater pollutant. Cyanobacteria produce secondary metabolites including cyanotoxins that pollute drinking and recreational waters and produce metabolites and cell components that can contribute to skin irritation. The aim of this study is to elucidate the specific mechanisms that lead to inflammation and irritation caused by exposure to these toxins. Multiplexing technology afforded the ability to investigate a variety of human cytokines and chemokines, and soluble receptors to measure immune responses in a single sample. 3D human tissue cultures were exposed to a variety of different toxins found in HABs. These samples were then examined using Luminex™ xMAP technology to look at 38 different cytokines/chemokines and 14 soluble receptors in each sample. We observed the expression of several cytokines/chemokines that regulate the inflammatory process in endothelial and epithelial cells and play a role in the recruitment of neutrophils to the site of inflammation. This could contribute to the rashes or skin irritation commonly reported by patients exposed to HABs. Additional observations and analyses are needed to identify the specific immune response pathways activated during exposure to these toxins. These findings could lead to a better understand of human exposure to cyanotoxins and more appropriate and effective treatment modalities for patients who exhibit rashes or skin irritations after being exposed to these blooms. This work is supported by the United States Environmental Protection Agency.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
楼下的闷倒驴完成签到,获得积分20
刚刚
rl_soccer发布了新的文献求助10
1秒前
cyan发布了新的文献求助10
2秒前
2秒前
送送完成签到,获得积分20
2秒前
鸣蜩阿六发布了新的文献求助10
2秒前
5秒前
5秒前
6秒前
lucas完成签到,获得积分10
7秒前
小蘑菇应助送送采纳,获得10
8秒前
惟依发布了新的文献求助30
9秒前
Li猪猪发布了新的文献求助10
9秒前
fly完成签到,获得积分10
9秒前
fanfan发布了新的文献求助10
10秒前
gin完成签到,获得积分10
11秒前
lucas发布了新的文献求助10
11秒前
Ava应助蘇尼Ai采纳,获得10
11秒前
12秒前
Crush发布了新的文献求助10
12秒前
zzz完成签到,获得积分10
13秒前
13秒前
科研通AI5应助飘逸水云采纳,获得10
13秒前
15秒前
zhutae应助悦耳怜珊采纳,获得10
15秒前
15秒前
17秒前
柒咩咩完成签到 ,获得积分10
17秒前
里lilili发布了新的文献求助10
17秒前
18秒前
rl_soccer发布了新的文献求助10
21秒前
22秒前
33发布了新的文献求助10
23秒前
23秒前
Seive发布了新的文献求助10
23秒前
考研小白发布了新的文献求助10
24秒前
上官若男应助科研通管家采纳,获得10
24秒前
Ava应助科研通管家采纳,获得10
24秒前
shouyu29应助科研通管家采纳,获得10
24秒前
华仔应助科研通管家采纳,获得10
24秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
Teaching language in context (Third edition) by Derewianka, Beverly; Jones, Pauline 550
Typology of Conditional Constructions 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3584123
求助须知:如何正确求助?哪些是违规求助? 3153282
关于积分的说明 9496164
捐赠科研通 2855890
什么是DOI,文献DOI怎么找? 1569749
邀请新用户注册赠送积分活动 735617
科研通“疑难数据库(出版商)”最低求助积分说明 721300