Palladium-catalyzed C-N Coupling Reactions in the Synthesis of Dibenzodiazepines

Abstract: In today’s world, aryl halides have attracted our attention toward the amination reactions catalyzed by palladium. In this review article, there are some selected developments in the field of catalysis, and the Buchwald-Hartwig amination reaction is one of them. It is a common and highly efficient method reported for forming dibenzodiazepines. The readily accessible precursors and ammonia undergo cross-coupling reactions in the presence of a palladium catalyst; after that, the intermediate immediately undergoes intramolecular condensation to give the desired dibenzodiazepines in one step. Due to the structural characteristics of these compounds, the potential for diversification - principally for functional group incorporation - is immense. New and advanced technologies are also employed to form these medicinally important molecules and are reviewed here. Our purpose is to inform the researchers about recent advances in this protocol for the C-N bond formation, especially used for synthesizing dibenzodiazepines.