体内
适体
生物传感器
材料科学
纳米技术
场效应晶体管
晶体管
核酸
生物医学工程
神经递质
石墨烯
化学
生物
生物化学
医学
电气工程
电压
受体
分子生物学
生物技术
工程类
作者
Ying Zhou,Binzhu Liu,Yongmin Lei,Lina Tang,Tingxian Li,Shanshan Yu,Guo‐Jun Zhang,Yutao Li
出处
期刊:Small
[Wiley]
日期:2022-11-07
卷期号:18 (52)
被引量:17
标识
DOI:10.1002/smll.202204142
摘要
Abstract Chemical communication via neurotransmitters is central to brain functions. Nevertheless, in vivo real‐time monitoring of neurotransmitters released in the brain, especially the electrochemically inactive molecules, remains a great challenge. In this work, a novel needle field‐effect transistor (FET) microsensor based on an acupuncture needle is proposed, which is demonstrated to be capable of real‐time monitoring dopamine molecules as well as neuropeptide Y in vivo. The FET microstructure is fabricated by successively wrapping an insulating layer and a gold layer on the top of the needle, where the needle and the Au served as the source and drain, respectively. After assembling reduced graphene oxide (RGO) between the source and drain electrodes, the specific aptamer is immobilized on the RGO, making this needle‐FET biosensor highly selective and sensitive to real‐time monitor neurotransmitters released from rat brain, even in a Parkinson's diseases model. Furthermore, the needle‐FET biosensor is applied to detect a variety of targets including hormones, proteins, and nucleic acid. By constructing a FET sensing interface on an acupuncture needle and implanting the sensor in a rat's brain for in vivo detection, this work provides a new sight in the FET domain and further expands the species of real‐time in vivo detection.
科研通智能强力驱动
Strongly Powered by AbleSci AI