An Integrative Approach to Explore Potent Therapeutic Protein Targets in Multidrug-resistant Nosocomial Pathogen Acinetobacter Baumannii

Therapeutic Protein Targets for Drug Discovery and Clinical Evaluation, pp. 159-193 (2022) No Access7: An Integrative Approach to Explore Potent Therapeutic Protein Targets in Multidrug-resistant Nosocomial Pathogen Acinetobacter BaumanniiJeyaraman Jeyakanthan, Chitra Jeyaraj Pandian, Jeba Mercy Jeyaseelan, Sundarraj Rajamanikandan, Dhamodharan Prabhu, Guru Raj Rao Ravi, Mutharasappan Nachiappan, and Jemima KingsleyJeyaraman JeyakanthanStructural Biology and Bio-Computing Lab, Department of Bioinformatics, Science Block, Alagappa University, Karaikudi, Tamil Nadu, IndiaCorresponding author:, Chitra Jeyaraj PandianDepartment of Biotechnology, Dr. Umayal Ramanathan College for Women, Karaikudi, Tamil Nadu, India, Jeba Mercy JeyaseelanDepartment of Biotechnology, Dr. Umayal Ramanathan College for Women, Karaikudi, Tamil Nadu, India, Sundarraj RajamanikandanStructural Biology and Bio-Computing Lab, Department of Bioinformatics, Science Block, Alagappa University, Karaikudi, Tamil Nadu, India, Dhamodharan PrabhuStructural Biology and Bio-Computing Lab, Department of Bioinformatics, Science Block, Alagappa University, Karaikudi, Tamil Nadu, India, Guru Raj Rao RaviStructural Biology and Bio-Computing Lab, Department of Bioinformatics, Science Block, Alagappa University, Karaikudi, Tamil Nadu, India, Mutharasappan NachiappanStructural Biology and Bio-Computing Lab, Department of Bioinformatics, Science Block, Alagappa University, Karaikudi, Tamil Nadu, India, and Jemima KingsleyOrbito Asia Diagnostics, Puliakulam Rd, Coimbatore, Tamil Nadu, Indiahttps://doi.org/10.1142/9789811254796_0007Cited by:0 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail Abstract: Acinetobacter baumannii is one of the multidrug resistant (MDR) pathogens responsible for nosocomial infection causing bacteremia, urinary tract infection, and surgical wound infection. Moreover, A. baumannii forms biofilms and survives for several days in a dry environment contributing to its endemic infections in hospital installations. Therefore, the occurrence of extreme drug-resistant or MDR strains of A. baumannii due to biofilm formation and quorum sensing (QS) is posing a foremost challenge to the medical community. In this regard, an integrative approach including protein crystallography of therapeutic targets in A. baumannii, in vitro evaluation of bacterial adhesion for biofilm formation, in vivo QS activity, and structure-based drug design targeting the therapeutic proteins will provide the alternative options to combat A. baumannii infections. The chapter will provide a complete overview of all potential therapeutic protein targets in A. baumannii that aid in designing novel drugs or inhibitors. FiguresReferencesRelatedDetails Therapeutic Protein Targets for Drug Discovery and Clinical EvaluationMetrics History PDF download