医学
纳米纤维
糖尿病溃疡
伤口愈合
静电纺丝
糖尿病
伤口敷料
糖尿病足
外科
纳米技术
材料科学
复合材料
内分泌学
聚合物
作者
Yukang Liu,Chaofei Li,Zhangbin Feng,Biao Han,Deng‐Guang Yu,Ke Wang
出处
期刊:Biomolecules
[MDPI AG]
日期:2022-11-22
卷期号:12 (12): 1727-1727
被引量:41
摘要
Chronic diabetic wounds are one of the main complications of diabetes, manifested by persistent inflammation, decreased epithelialization motility, and impaired wound healing. This will not only lead to the repeated hospitalization of patients, but also bear expensive hospitalization costs. In severe cases, it can lead to amputation, sepsis or death. Electrospun nanofibers membranes have the characteristics of high porosity, high specific surface area, and easy functionalization of structure, so they can be used as a safe and effective platform in the treatment of diabetic wounds and have great application potential. This article briefly reviewed the pathogenesis of chronic diabetic wounds and the types of dressings commonly used, and then reviewed the development of electrospinning technology in recent years and the advantages of electrospun nanofibers in the treatment of diabetic wounds. Finally, the reports of different types of nanofiber dressings on diabetic wounds are summarized, and the method of using multi-drug combination therapy in diabetic wounds is emphasized, which provides new ideas for the effective treatment of diabetic wounds.
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