Combined photoredox/engineered P450 enzymatic direct dioxygen-functionalization of arylalkanes to chiral acyloins

This study has described an efficient, mild, and highly enantioselective one-pot two-step cascade reaction to access chiral α-hydroxyketones from arylalkanes, combining photoredox/P450 enzymatic direct dioxygen-functionalization of arylalkanes α/β C–H bonds.