胎粪吸入综合征
胎粪
炎症
免疫学
细胞凋亡
医学
肺
发病机制
呼吸窘迫
病理
生物
麻醉
内科学
胎儿
怀孕
生物化学
遗传学
作者
Daniel Mota‐Rojas,Dina Villanueva‐García,Andrea Mota-Reyes,Agustı́n Orihuela,Ismael Hernández-Ávalos,Adriana Domínguez-Oliva,Alejandro Casas-Alvarado,Karla Flores-Padilla,Joseline Jacome-Romero,Julio Martı́nez-Burnes
出处
期刊:Animals
[MDPI AG]
日期:2022-11-27
卷期号:12 (23): 3310-3310
被引量:7
摘要
Meconium Aspiration Syndrome is a condition that causes respiratory distress in newborns due to occlusion and airway inflammation, and surfactant inactivation by meconium. This condition has been described in animal species such as canids, sheep, cattle, horses, pigs, and marine mammals. In its pathogenesis, the pulmonary epithelium activates a limited inflammatory response initiated by cytokines causing leukocyte chemotaxis, inhibition of phagocytosis, and pathogen destruction. Likewise, cytokines release participates in the apoptosis processes of pneumocytes due to the interaction of angiotensin with cytokines and the caspase pathway. Due to these reactions, the prevalent signs are lung injury, hypoxia, acidosis, and pneumonia with susceptibility to infection. Given the importance of the pathophysiological mechanism of meconium aspiration syndrome, this review aims to discuss the relevance of the syndrome in veterinary medicine. The inflammatory processes caused by meconium aspiration in animal models will be analyzed, and the cellular apoptosis and biochemical processes of pulmonary surfactant inactivation will be discussed.
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