Computed Tomography-based Radiomics Evaluation of Postoperative Local Recurrence of Pancreatic Ductal Adenocarcinoma

列线图 医学 接收机工作特性 胰腺导管腺癌 放射科 无线电技术 队列 曲线下面积 鉴别诊断 胰腺癌 内科学 病理 癌症
作者
Ming He,Xinyue Chen,Michael Wels,Félix Lades,Yatong Li,Zaiyi Liu,Zhengyu Jin,Huadan Xue
出处
期刊:Academic Radiology [Elsevier BV]
卷期号:30 (4): 680-688 被引量:6
标识
DOI:10.1016/j.acra.2022.05.019
摘要

To develop and validate an effective model for identifying patients with postoperative local disease recurrence of pancreatic ductal adenocarcinoma (PDAC).A total of 153 patients who had undergone surgical resection of PDAC with regular postoperative follow-up were consecutively enrolled and randomly divided into training (n = 108) and validation (n = 45) cohorts. The postoperative soft-tissue biopsy results or clinical follow-up results served as the reference diagnostic criteria. Radiomics analysis of the postoperative soft-tissue was performed on a commercially available prototype software using portal vein phase image. Three models were built to characterize postoperative soft tissue: computed tomography (CT)-based radiomics, clinicoradiological, and their combination. The area under the receiver operating characteristic curves (AUC) was used to evaluate the differential diagnostic performance. A nomogram was used to select the final model with best performance. One radiologist's diagnostic choices that were made with and without the nomogram's assistance were evaluated.A seven-feature-combined radiomics signature was constructed as a predictor of postoperative local recurrence. The nomogram model combining the radiomics signature with postoperative CA 19-9 elevation showed the best performance (training cohort, AUC = 0.791 [95%CI: 0.707, 0.876]; validation cohort, AUC = 0.742 [95%CI: 0.590, 0.894]). In the validation cohort, the AUC for differential diagnosis was significantly improved for the combined model relative to that for postoperative CA 19-9 elevation (AUC = 0.742 vs. 0.533, p < 0.001). The calibration curve and decision curve analysis demonstrated the clinical usefulness of the proposed nomogram. The diagnostic performance of the radiologist was not significantly improve by using the proposed nomogram (AUC = 0.742 vs. 0.670, p = 0.17).The combined model using CT radiomic features and CA 19-9 elevation effectively characterized postoperative soft tissue and potentially may improve treatment strategies and facilitate personalized treatment for PDAC after surgical resection.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
顾大喵完成签到,获得积分10
1秒前
小虫虫完成签到,获得积分10
1秒前
lwwww完成签到,获得积分10
2秒前
吨吨喝水完成签到,获得积分10
3秒前
文献文献文献完成签到,获得积分10
4秒前
温眼张完成签到,获得积分10
4秒前
Orange应助HM采纳,获得10
4秒前
4秒前
隔水一路秋完成签到,获得积分10
5秒前
ah_junlei完成签到,获得积分10
5秒前
Simon完成签到,获得积分10
6秒前
小科完成签到,获得积分10
6秒前
完美世界应助熊二浪采纳,获得10
7秒前
了尘完成签到,获得积分10
7秒前
无心的天真完成签到 ,获得积分10
8秒前
彪壮的绮烟完成签到,获得积分10
8秒前
欣然完成签到 ,获得积分10
8秒前
琮博完成签到,获得积分10
8秒前
量子星尘发布了新的文献求助10
9秒前
NB完成签到,获得积分10
10秒前
波哥发布了新的文献求助20
10秒前
dyk完成签到,获得积分10
12秒前
hbj完成签到,获得积分10
13秒前
13秒前
Fang Xianxin完成签到,获得积分10
13秒前
无忧无虑完成签到,获得积分10
14秒前
missionary完成签到,获得积分10
14秒前
悦007完成签到,获得积分10
15秒前
启程牛牛完成签到,获得积分0
16秒前
wonder完成签到,获得积分10
16秒前
大力不弱完成签到,获得积分10
19秒前
19秒前
罗rr完成签到 ,获得积分10
20秒前
afli完成签到 ,获得积分0
20秒前
AZE应助一路向南采纳,获得10
21秒前
Jessica完成签到 ,获得积分10
22秒前
晨光中完成签到,获得积分10
23秒前
xc完成签到,获得积分10
23秒前
Ava应助冷静的万言采纳,获得10
23秒前
24秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 1000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976768
求助须知:如何正确求助?哪些是违规求助? 3520874
关于积分的说明 11205018
捐赠科研通 3257788
什么是DOI,文献DOI怎么找? 1798842
邀请新用户注册赠送积分活动 877927
科研通“疑难数据库(出版商)”最低求助积分说明 806694