Combination of edge enhancement and cold diffusion model for low dose CT image denoising

Abstract Objectives Since the quality of low dose CT (LDCT) images is often severely affected by noise and artifacts, it is very important to maintain high quality CT images while effectively reducing the radiation dose. Methods In recent years, the representation of diffusion models to produce high quality images and stable trainability has attracted wide attention. With the extension of the cold diffusion model to the classical diffusion model, its application has greater flexibility. Inspired by the cold diffusion model, we proposes a low dose CT image denoising method, called CECDM, based on the combination of edge enhancement and cold diffusion model. The LDCT image is taken as the end point (forward) of the diffusion process and the starting point (reverse) of the sampling process. Improved sobel operator and Convolution Block Attention Module are added to the network, and compound loss function is adopted. Results The experimental results show that CECDM can effectively remove noise and artifacts from LDCT images while the inference time of a single image is reduced to 0.41 s. Conclusions Compared with the existing LDCT image post-processing methods, CECDM has a significant improvement in all indexes.