组蛋白
表观遗传学
乙酰化
生物
组蛋白乙酰转移酶
染色质
癌变
癌症
癌症研究
组蛋白脱乙酰基酶
染色质重塑
组蛋白修饰酶
细胞生物学
遗传学
基因
作者
Xiaohong Duan,Zhiyao Xing,Lu Qiao,Shan Qin,Xuejing Zhao,Yanhua Gong,Xueren Li
标识
DOI:10.3389/fimmu.2024.1495221
摘要
Histones play crucial roles in both promoting and repressing gene expression, primarily regulated through post-translational modifications (PTMs) at specific amino acid residues. Histone PTMs, including methylation, acetylation, ubiquitination, phosphorylation, lactylation, butyrylation, and propionylation, act as important epigenetic markers. These modifications influence not only chromatin compaction but also gene expression. Their importance extends to the treatment and prevention of various human diseases, particularly cancer, due to their involvement in key cellular processes. Abnormal histone modifications and the enzymes responsible for these alterations often serve as critical drivers in tumor cell proliferation, invasion, apoptosis, and stemness. This review introduces key histone PTMs and the enzymes responsible for these modifications, examining their impact on tumorigenesis and cancer progression. Furthermore, it explores therapeutic strategies targeting histone PTMs and offers recommendations for identifying new potential therapeutic targets.
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