Correlation analysis between renal clear cell carcinoma and BAP1

Renal clear cell carcinoma (ccRCC) is the most typical pathological type of renal carcinoma (RCC), accounting for about 75%. The pathogenesis of ccRCC is a complex process in which multiple factors or multiple gene variations act together and affect each other. With the deepening research of ccRCC and the development of next-generation sequencing, genomics has been recognized and widely used in cancer research. At present, the mutant gene map of renal clear cell carcinoma has been obtained by high-throughput targeted sequencing, in which the mutant gene BAP1 is a typical tumor suppressor gene. Studies have found that the mutation of BAP1 is closely related to the development and progression of ccRCC. BAP1 mutation is ubiquitous in ccRCC, and has attracted more and more scholars' research interest. Fruitful research results have been obtained, which is of great significance for the early diagnosis and targeted therapy of ccRCC. BAP1 may play a protective role in the development of CCRCC, and its mutation is a marker of poor prognosis in CCRCC. The pathogenesis, proliferation, biological activity, clinical stage and prognosis of renal clear cell carcinoma are all related to the expression and function of BAP1. BAP1 plays an important role in the development of renal clear cell carcinoma.