钙
平衡
钙代谢
细胞生物学
生物学中的钙
细胞内
细胞外
第二信使系统
生物
分泌物
运输机
钙泵
钙信号传导
钙通道
化学
内分泌学
内科学
生物化学
医学
ATP酶
酶
基因
作者
Ghassan Bkaily,Danielle Jacques
摘要
Calcium is a highly positively charged ionic species. It regulates all cell types’ functions and is an important second messenger that controls and triggers several mechanisms, including membrane stabilization, permeability, contraction, secretion, mitosis, intercellular communications, and in the activation of kinases and gene expression. Therefore, controlling calcium transport and its intracellular homeostasis in physiology leads to the healthy functioning of the biological system. However, abnormal extracellular and intracellular calcium homeostasis leads to cardiovascular, skeletal, immune, secretory diseases, and cancer. Therefore, the pharmacological control of calcium influx directly via calcium channels and exchangers and its outflow via calcium pumps and uptake by the ER/SR are crucial in treating calcium transport remodeling in pathology. Here, we mainly focused on selective calcium transporters and blockers in the cardiovascular system.
科研通智能强力驱动
Strongly Powered by AbleSci AI