血管生成
生物
免疫系统
体内
细胞生物学
细胞
癌症研究
免疫学
生物技术
生物化学
作者
Ge Zhang,Xinli Liu,Yali Liu,Shilong Zhang,Tongyao Yu,Xiaoxia Chai,Jinliang He,Da‐Chuan Yin,Chen‐Yan Zhang
标识
DOI:10.1016/j.pbiomolbio.2023.04.001
摘要
Malignancies are the leading human health threat worldwide. Despite rapidly developing treatments, poor prognosis and outcome are still common. Magnetic fields have shown good anti-tumoral effects both in vitro and in vivo, and represent a potential non-invasive treatment; however, the specific underlying molecular mechanisms remain unclear. We here review recent studies on magnetic fields and their effect on tumors at three different levels: organismal, cellular, and molecular. At the organismal level, magnetic fields suppress tumor angiogenesis, microcirculation, and enhance the immune response. At the cellular level, magnetic fields affect tumor cell growth and biological functions by affecting cell morphology, cell membrane structure, cell cycle, and mitochondrial function. At the molecular level, magnetic fields suppress tumors by interfering with DNA synthesis, reactive oxygen species level, second messenger molecule delivery, and orientation of epidermal growth factor receptors. At present, scientific experimental evidence is still lacking; therefore, systematic studies on the biological mechanisms involved are urgently needed for the future application of magnetic fields to tumor treatment.
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