自愈水凝胶
透明质酸
活性氧
细胞外基质
明胶
炎症
再生(生物学)
肿瘤微环境
化学
细胞生物学
材料科学
生物物理学
免疫学
生物化学
医学
免疫系统
解剖
生物
高分子化学
作者
Feng Han,Zhengdong Tu,Zhuang Zhu,Dachuan Liu,Qingchen Meng,Qifan Yu,Ying Wang,Jianquan Chen,Tao Liu,Fengxuan Han,Bin Li
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-04-06
卷期号:17 (8): 7645-7661
被引量:40
标识
DOI:10.1021/acsnano.3c00093
摘要
The excessive reactive oxygen species (ROS) level, inflammation, and weak tissue regeneration ability after annulus fibrosus (AF) injury constitute an unfavorable microenvironment for AF repair. AF integrity is crucial for preventing disc herniation after discectomy; however, there is no effective way to repair the AF. Herein, a composite hydrogel integrating properties of antioxidant, anti-inflammation, and recruitment of AF cells is developed through adding mesoporous silica nanoparticles modified by ceria and transforming growth factor β3 (TGF-β3) to the hydrogels. The nanoparticle loaded gelatin methacrylate/hyaluronic acid methacrylate composite hydrogels eliminate ROS and induce anti-inflammatory M2 type macrophage polarization. The released TGF-β3 not only plays a role in recruiting AF cells but is also responsible for promoting extracellular matrix secretion. The composite hydrogels can be solidified in situ in the defect area to effectively repair AF in rats. The strategies targeting endogenous ROS removal and improving the regenerative microenvironment by the nanoparticle-loaded composite hydrogels have potential applications in AF repair and intervertebral disc herniation prevention.
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