免疫监视
免疫系统
逃避(道德)
免疫学
癌症
干扰素
细胞因子
免疫逃逸
免疫疗法
癌细胞
生物
癌症研究
医学
遗传学
作者
Yueyue Chen,Ningning Niu,Jing Xue
标识
DOI:10.1097/jp9.0000000000000113
摘要
Interferon-gamma (IFNγ) is a pleiotropic cytokine implicated in tumor immune surveillance, with its antiproliferative, pro-apoptotic, and immune-provoking effects. Regarding the antitumor effects of IFNγ, IFNγ-dependent therapies have been proposed and have undergone many clinical trials for various cancer types but the outcomes were not satisfactory. Recent studies have suggested that cancer cells develop immune evasion strategies to escape from IFNγ-dependent immunosurveillance by various mechanisms. In this review, we summarize recent advances in the effects and molecular mechanisms of IFNγ on target cells, as well as potential immune escape mechanisms of tumor cells. Furthermore, we discuss how to target IFNγ signaling and overcome immune evasion to provide promising therapeutic strategies for the treatment of patients with cancer.
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