Human Bone Marrow–derived Clonal Mesenchymal Stem Cells Decrease the Initial C-Reactive Protein Level in Patients With Moderately Severe to Severe Acute Pancreatitis

The pathophysiologic mechanism of acute pancreatitis (AP) involves autodigestion after activation of digestive enzymes. After the activation of acinar cells, chemokines promote the aggregation of helper T cells and macrophages. 1 Pandol S.J. et al. Gastroenterology. 2007; 132: 1127-1151 Abstract Full Text Full Text PDF PubMed Scopus (494) Google Scholar This induces the production of inflammatory cytokines (interleukin [IL]-1β, IL-4, IL-5, IL-6, IL-10, interferon-γ, and tumor necrosis factor-α), thereby triggering inflammatory cascades and leading to systemic inflammatory response syndrome, multiorgan failure, and, in some cases, death. 1 Pandol S.J. et al. Gastroenterology. 2007; 132: 1127-1151 Abstract Full Text Full Text PDF PubMed Scopus (494) Google Scholar ,2 Malmstrøm M.L. et al. Pancreas. 2012; 41: 271-277 Crossref PubMed Scopus (117) Google Scholar