内分泌学
内科学
外围设备
抑制性突触后电位
受体
促性腺激素
5-羟色胺受体
激素
能量代谢
生物
血清素
医学
作者
Xingxing Song,Wenhao Xu,Zixin Li,Xin Zhang,Chengcheng Liu,Kaiou Han,Lei Chen,Yan Shi,Changlin Xu,Dongyang Han,Rongrong Luo,Yajie Cao,Qingwen Li,Huihua Yang,Qiucheng Lu,Jin Qin,Xiaoye Wang,Chuanhuo Hu,Xun� Li
出处
期刊:Neuroendocrinology
[S. Karger AG]
日期:2024-01-01
卷期号:114 (8): 749-774
摘要
<b><i>Introduction:</i></b> Since the discovery of gonadotropin-inhibitory hormone (GnIH), it has been found to play a critical role in reproduction in vertebrates. Recently, a regulatory role of GnIH in appetite and energy metabolism has emerged, although its precise physiological mechanisms remain unknown. <b><i>Methods:</i></b> Thus, the present study evaluated the effects of a single or long-term intraperitoneal GnIH treatment on the food intake, weight, and glucolipid metabolism of chickens, as well as investigating the possible neuroendocrinology factors and mechanisms involved in GnIH-induced obesity and glucolipid metabolism disorder. <b><i>Results:</i></b> Our results show that the intraperitoneal administration of GnIH to chickens resulted in a marked body mass increase, hyperlipidemia, hyperglycemia, and glucose intolerance. Subsequently, the results of metabolomics studies and the pharmacological inhibition of the 5-HT2C receptor revealed that blocking the 5-HT2C receptor reinforced the effects of GnIH on food intake, body weight, and blood glucose and lipid levels, resulting in even worse cases of GnIH-induced hyperglycemia, hyperlipidemia, and hepatic lipid deposition. This suggests that, via the 5-HT2C receptor, peripheral 5-HT may act as a negative feedback regulator to interplay with GnIH and jointly control energy balance homeostasis in chickens. <b><i>Discussion:</i></b> Our present study provides evidence of cross-talk between GnIH and 5-HT in food intake and energy metabolism at the in vivo pharmacological level, and it proposes a molecular basis for these interactions, suggesting that functional interactions between GnIH and 5-HT may open new avenues for understanding the mechanism of the neuroendocrine network involved in appetite and energy metabolism, as well as providing a new therapeutic strategy to prevent obesity, diabetes, and metabolic disorders.